Snail expression is an independent predictor of tumor recurrence in superficial bladder cancers
Identifieur interne : 007536 ( Main/Exploration ); précédent : 007535; suivant : 007537Snail expression is an independent predictor of tumor recurrence in superficial bladder cancers
Auteurs : Franck Bruyere [France] ; Benjamin Namdarian [Australie] ; Niall M. Corcoran [Australie] ; John Pedersen [Australie] ; Jeremy Ockrim [Royaume-Uni] ; Bryan B. Voelzke [États-Unis] ; Uttam Mete [Inde] ; Anthony J. Costello [Australie] ; Christopher M. Hovens [Australie]Source :
- Urologic oncology [ 1078-1439 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: Epithelial-mesenchymal transition (EMT) is known to play an important role in the development of tumor invasion and progression in tumors of epithelial origin. Objectives: Our aim was to investigate the role of Snail transcription repressor family members in human bladder pathogenesis. Material and methods: We evaluated levels of Snail and Slug in 87 patients who received transurethral resection of a transitional cell carcinoma at our institution during the period from June 1999 until November 2003. Immunohistochemistry was performed on tissue microarrays, and expression correlated with pathological variables and clinical outcomes. Degree and intensity of Snail and Slug staining was quantified by immunohistochemistry. Results: There was no apparent enrichment in strong vs. weak staining for either Snail (43.7% vs. 56.3%) or Slug (46% vs. 54%) in the superficial bladder tumors. Univariate analysis determined that tumor focality and Snail expression were significantly associated with tumor recurrence (P < 0.05). Only for tumor focality did such a relationship exist when assessing tumor progression. Multivariate analysis using the Cox's proportional hazards model revealed similar results to that of the univariate analysis. Snail expression (P = 0.038) and tumor focality (P = 0.011) were independent and significant prognostic factors for tumor recurrence in all patients. However, only tumor focality was an independent predictor of tumor progression (P = 0.034). Conclusions: High expression of Snail in superficial bladder tumors is a strong predictor of tumor recurrence enhancing risk stratification and prognostication.
Affiliations:
- Australie, France, Inde, Royaume-Uni, États-Unis
- Angleterre, Centre-Val de Loire, Grand Londres, Région Centre, Victoria (État)
- Londres, Melbourne, Tours
- Université de Melbourne
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Voelzke</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>University of California</s1><s2>San Francisco, CA 94143</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>University of California</wicri:noRegion></affiliation></author><author><name sortKey="Mete, Uttam" sort="Mete, Uttam" uniqKey="Mete U" first="Uttam" last="Mete">Uttam Mete</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Postgraduate Institute of Medical Education and Research</s1><s2>Chandigarh</s2><s3>IND</s3><sZ>7 aut.</sZ></inist:fA14><country>Inde</country><wicri:noRegion>Postgraduate Institute of Medical Education and Research</wicri:noRegion></affiliation></author><author><name sortKey="Costello, Anthony J" sort="Costello, Anthony J" uniqKey="Costello A" first="Anthony J." last="Costello">Anthony J. Costello</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Departments of Urology and Surgery, Royal Melbourne Hospital, University of Melbourne</s1><s2>Parkville</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Hovens, Christopher M" sort="Hovens, Christopher M" uniqKey="Hovens C" first="Christopher M." last="Hovens">Christopher M. Hovens</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Departments of Urology and Surgery, Royal Melbourne Hospital, University of Melbourne</s1><s2>Parkville</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author></analytic><series><title level="j" type="main">Urologic oncology</title><title level="j" type="abbreviated">Urol. oncol.</title><idno type="ISSN">1078-1439</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Urologic oncology</title><title level="j" type="abbreviated">Urol. oncol.</title><idno type="ISSN">1078-1439</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancerology</term><term>Carcinoma</term><term>Immunohistochemistry</term><term>Nephrology</term><term>Non muscle invasive bladder cancer</term><term>Predictive factor</term><term>Prognosis</term><term>Relapse</term><term>Snail</term><term>Urology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Escargot</term><term>Pronostic</term><term>Facteur prédictif</term><term>Récidive</term><term>Immunohistochimie</term><term>Carcinome</term><term>Cancérologie</term><term>Néphrologie</term><term>Urologie</term><term>Tumeur de vessie n'infiltrant pas le muscle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Epithelial-mesenchymal transition (EMT) is known to play an important role in the development of tumor invasion and progression in tumors of epithelial origin. Objectives: Our aim was to investigate the role of Snail transcription repressor family members in human bladder pathogenesis. Material and methods: We evaluated levels of Snail and Slug in 87 patients who received transurethral resection of a transitional cell carcinoma at our institution during the period from June 1999 until November 2003. Immunohistochemistry was performed on tissue microarrays, and expression correlated with pathological variables and clinical outcomes. Degree and intensity of Snail and Slug staining was quantified by immunohistochemistry. Results: There was no apparent enrichment in strong vs. weak staining for either Snail (43.7% vs. 56.3%) or Slug (46% vs. 54%) in the superficial bladder tumors. Univariate analysis determined that tumor focality and Snail expression were significantly associated with tumor recurrence (P < 0.05). Only for tumor focality did such a relationship exist when assessing tumor progression. Multivariate analysis using the Cox's proportional hazards model revealed similar results to that of the univariate analysis. Snail expression (P = 0.038) and tumor focality (P = 0.011) were independent and significant prognostic factors for tumor recurrence in all patients. However, only tumor focality was an independent predictor of tumor progression (P = 0.034). Conclusions: High expression of Snail in superficial bladder tumors is a strong predictor of tumor recurrence enhancing risk stratification and prognostication.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Inde</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Centre-Val de Loire</li><li>Grand Londres</li><li>Région Centre</li><li>Victoria (État)</li></region><settlement><li>Londres</li><li>Melbourne</li><li>Tours</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="France"><region name="Centre-Val de Loire"><name sortKey="Bruyere, Franck" sort="Bruyere, Franck" uniqKey="Bruyere F" first="Franck" last="Bruyere">Franck Bruyere</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Namdarian, Benjamin" sort="Namdarian, Benjamin" uniqKey="Namdarian B" first="Benjamin" last="Namdarian">Benjamin Namdarian</name></region><name sortKey="Corcoran, Niall M" sort="Corcoran, Niall M" uniqKey="Corcoran N" first="Niall M." last="Corcoran">Niall M. Corcoran</name><name sortKey="Costello, Anthony J" sort="Costello, Anthony J" uniqKey="Costello A" first="Anthony J." last="Costello">Anthony J. Costello</name><name sortKey="Hovens, Christopher M" sort="Hovens, Christopher M" uniqKey="Hovens C" first="Christopher M." last="Hovens">Christopher M. Hovens</name><name sortKey="Pedersen, John" sort="Pedersen, John" uniqKey="Pedersen J" first="John" last="Pedersen">John Pedersen</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ockrim, Jeremy" sort="Ockrim, Jeremy" uniqKey="Ockrim J" first="Jeremy" last="Ockrim">Jeremy Ockrim</name></region></country><country name="États-Unis"><noRegion><name sortKey="Voelzke, Bryan B" sort="Voelzke, Bryan B" uniqKey="Voelzke B" first="Bryan B." last="Voelzke">Bryan B. Voelzke</name></noRegion></country><country name="Inde"><noRegion><name sortKey="Mete, Uttam" sort="Mete, Uttam" uniqKey="Mete U" first="Uttam" last="Mete">Uttam Mete</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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